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KMID : 0895820050150030055
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Journal of Oriental Rehabilitation Medicine
2005 Volume.15 No. 3 p.55 ~ p.73
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Anti-pathogenetic and Curative Effects of Radix Cortex Acanthopanacis Senticosi on the Collagen-Induced Arthritis in Wistar Rats
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Oh Chung-Hwan
Kim Soon-Joong
Seo Il-Bok
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Abstract
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Objectives: This study was carried out to investigated the anti-pathogenetic and curative effects of Radix Cortex Acanthopanacis Senticosis (CAS) on collagen-induced arthritis in rats.
Methods: In experiment Ⅰ, rats(n=30) were divided into normal group, porcine type II collagen immunized control group which taken with normal saline, and collagen immunized treated group which taken with extract of CAS. Body weight, paw edema volume, and thickness of ankle joint were measured at 0, 10, 15 days after immunization. At 15 days after immunization, serum TNF-α, IL-1β and anti-collagen IgG level were analysed, and histopathological examination was performed on the ankle joint. In experiment Ⅱ, rats(n=13) that were shown the gross lesions of collagen-induced arthritis, were divided into control group and treated group which taken with extract of CAS for 15 days after onset of arthritis. Items and methods of measurement were the same as experiment Ⅰ.
Results: In experiment I, the results were as follows ; Arthritic score, paw edema volume, thickness of ankle joint, TNF-α, anti-collagen IgG of treated group were significantly decreased. In experiment Ⅱ, the results were as follows ; Paw edema volume, TNF-α, IL-1β, anti-collagen IgG of treated group were significantly decreased.
Conclusions: These results indicated that CAS has the inhibitory effects on the incidence and progression of collagen-induced arthritis in rats.
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KEYWORD
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Radix Cortex Acanthopanacis Senticosis, Collagen-induced arthritis, TNF-α, IL-1β, Anti-collagen IgG
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